10-Ingredient Male Vitality Formula Upgraded for 2026

Apollon Nutrition has reformulated Casanova, their epic male vitality and performance supplement, with an upgraded 10-ingredient formula that delivers clinical doses of nitric oxide boosters, testosterone support compounds, and adaptogenic herbs. The 2026 version adds four new ingredients while maintaining the blood flow support that made the original popular, but with a cleaner formula that removes some of the more aggressive stimulant components.

Apollon Nutrition reformulated Casanova with 10 clinical-dosed ingredients for male vitality. New additions include ashwagandha, shilajit, and spilanthes acmella. Yohimbine removed. Features 1500mg Nitrosigine, upgraded 30% icariin horny goat weed, 500mg black ginger. Blood flow, testosterone support, stress management in one formula.

Each 8-capsule serving delivers 1500mg Nitrosigine® for nitric oxide production, a large 1000mg horny goat weed extract (now standardized to 30% icariin), and 600mg each of Testofen® fenugreek, tongkat ali, and a new form of ashwagandha. The formula targets multiple pathways: blood flow optimization, testosterone support, stress management, and libido enhancement. For guys who want comprehensive support rather than single-ingredient shortcuts, Casanova covers the bases in one product.

Casanova: Blood Flow Beyond the Gym

Nitric oxide isn’t just for workout pumps — the NO support in Casanova is for sexual performance, too! With 1500mg Nitrosigine® leading the formula, you’re getting the same blood flow benefits that make this ingredient popular in pre-workouts. This makes Casanova versatile: you can take it daily for overall vitality or time it pre-workout for pump and performance benefits alongside the hormonal support. Stack it with The Specialist for complete organ protection, or add CreaSmash for additional blood flow and ATP support.

The 224-capsule bottle (28 servings) is a perfect example of Apollon’s approach: massive, clinical doses in every serving and absolutely no compromises. If you’re looking for a comprehensive male health formula that goes beyond basic testosterone support, check for availability below and sign up for Apollon Nutrition news alerts. Then we’ll get into the ingredients.

Apollon Nutrition Casanova Ingredients

Each 8-capsule serving provides the following:

• Inositol Stabilized Arginine Silicate (as Nitrosigine®) – 1500mg

  Nitrosigine is an inositol-stabilized arginine silicate complex that supports nitric oxide production through increased arginine availability. Unlike standard L-arginine supplementation, which gets metabolized by the liver before entering circulation, Nitrosigine increases blood arginine levels within 30 minutes and maintains elevation for up to 6 hours.^[1] This rapid onset and sustained duration make it ideal for supporting blood flow during both training sessions and intimate activities.

  Research shows 1500mg increases flow-mediated dilation by 31%, matching the effects of 8g citrulline malate.^[2] The dose may also help reduce exercise-induced muscle damage markers like creatine kinase and myoglobin while supporting perceived energy levels.^[3]

  The silicon component appears to inhibit arginase, the enzyme that breaks down arginine, which helps explain Nitrosigine’s superior bioavailability. Studies show it increases plasma arginine by over 70% compared to arginine hydrochloride while maintaining these elevated levels significantly longer. For Casanova’s purposes, this translates to enhanced blood flow support for both athletic performance and sexual function.

  For a capsule-based product, using Nitrosigine over citrulline or L-arginine makes total sense given how much less space it takes up.

• Horny Goat Weed Extract (Epimedium grandiflorum) (aerial) (standardized to contain 30% Icariin) – 1000mg

  Apollon’s horny goat weed extract delivers 300mg of icariin, the primary bioactive flavonoid that supports healthy blood flow and erectile function through multiple complementary mechanisms. Icariin inhibits phosphodiesterase-5 (PDE5), the same enzyme targeted by prescription medications, while simultaneously supporting nitric oxide production in vascular tissue.^[4]

  

  Research in animal models shows that icariin enhances neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) expression in penile tissue, supporting the cGMP pathway that promotes smooth muscle relaxation.^[5] Studies using 1 to 5mg/kg in rats demonstrated improved intracavernosal pressure and increased penile nitric oxide synthase expression compared to untreated controls.

  The compound also demonstrates testosterone-mimetic properties in preclinical research, potentially supporting healthy hormone levels and reproductive function.^[6]

  The 30% standardization (up from 20% in the previous formula) ensures robust icariin concentrations that work synergistically with Nitrosigine® to optimize multiple blood flow pathways for comprehensive vascular support both in training and out.

• Testofen® Fenugreek Seed Extract (standardized to contain minimum 50% Fenuside™) – 600mg

  Testofen® is a fenugreek (Trigonella foenum-graecum) extract standardized to minimum 50% Fenuside, a branded complex of furostanol saponins that may support healthy testosterone levels and sexual function. The 600mg dose matches the clinically studied amount, where research in men aged 25 to 52 showed improvements in sexual arousal and orgasm alongside self-reported gains in muscle strength, energy, and well-being.^[7]

  Proposed mechanisms include potential modulation of 5-alpha-reductase and aromatase enzymes, which helps maintain normal testosterone availability by reducing conversion to other hormones.^[8] Research suggests furostanol saponins may support luteinizing hormone (LH) signaling, enhance testicular sensitivity to LH, and help maintain testosterone synthesis while reducing testosterone breakdown. A 2023 meta-analysis found a dose-response effect, with 600mg Testofen supporting testosterone levels more consistently than 300mg across multiple trials.^[8]

  

  Combined with Casanova’s blood flow support from Nitrosigine® and hormonal ingredients like tongkat ali, Testofen complements the formula’s multi-pathway approach to male vitality.

• Longjack Tongkat Ali (Eurycoma longifolia) Extract 100:1 (Root) – 600mg

  Next, Casanova delivers 600mg of a tongkat ali through a concentrated 100:1 root extract, providing the testosterone support that makes this Southeast Asian botanical a staple in male vitality formulas. The active compound eurycomanone works through two primary mechanisms: inhibiting aromatase (the enzyme that converts testosterone to estrogen) and supporting the hypothalamic-pituitary-gonadal axis to promote natural testosterone production.^[9]

  In a landmark study by Talbott et al., subjects taking 200mg daily experienced a 37% increase in testosterone alongside a 16% reduction in cortisol exposure after just four weeks, significantly improving the testosterone:cortisol ratio.^[10] These hormonal improvements translated to measurable reductions in tension, anger, and confusion scores.

  The 600mg dose in Casanova exceeds the effective research dose, supporting both hormonal optimization and stress management alongside the formula’s blood flow and nitric oxide benefits.

• WiS05X® (Withania somnifera) (Root) – 600mg

  Casanova continues with large doses, next bringing 500mg of WiS05X® ashwagandha root extract, targeting stress management and hormonal optimization through modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Research shows ashwagandha reduces cortisol while supporting testosterone production, making it particularly relevant for men experiencing stress-related hormonal decline.^[11]

  The active compounds, withanolides, work through multiple pathways: they help maintain healthy cortisol levels (elevated cortisol suppresses testosterone production), support GABA receptor activity for stress reduction, and may enhance luteinizing hormone signaling that drives testosterone synthesis.^[12] In aging males, an 8-week trial using ashwagandha extract demonstrated an 18% increase in DHEA-S and 14.7% increase in testosterone compared to placebo, alongside improvements in vitality markers.

  

  The 600mg dose here aligns with research showing benefits at 300mg to 600mg daily ranges for stress reduction and hormonal support. Within Casanova’s formula, ashwagandha complements the testosterone-focused ingredients (Testofen® and tongkat ali) by addressing the stress component that often undermines hormonal health, while the blood flow support from Nitrosigine® ensures the physical manifestation of these hormonal improvements.

• Spilanthes Acmella Extract (Flower) (SA3X™) (standardized to minimum 3.5% N-Alkylamides including Spilanthols) – 500mg

  Spilanthes acmella flower extract brings clinical research-backed testosterone and sexual function support through dual pathways: enhanced nitric oxide production and hormone modulation.

  The flower’s active compounds are N-alkylamides (including spilanthol), which research demonstrates support vasorelaxation and blood flow through nitric oxide-dependent mechanisms.^[13]

  In a three-month randomized controlled trial, 500mg daily supplementation of SA3X increased serum testosterone levels by an average of 22 ng/dL compared to placebo (p<0.001), with effects maintained three months after stopping supplementation.^[14] The same research team demonstrated significant improvements in erectile function scores and erection duration in men with low testosterone.^[15] Animal research suggests the mechanism involves upregulation of FSH and LH, supporting natural testosterone production rather than direct hormone supplementation.^[16]

  

  The SA3X group saw significantly greater improvements in serum testosterone, as well as MSHQ, IIEF, and erectile duration.^[17]

  The 500mg dose here matches the clinically-studied amount and complements the other blood flow and testosterone support ingredients throughout Casanova’s formula. Expect no less from Apollon, at this point.

• ASP5X® Purified Shilajit (Asphaltum) Extract – 500mg

  Shilajit is a mineral-rich adaptogen used for centuries in Ayurvedic medicine, composed primarily of fulvic acid along with dibenzo-α-pyrones and trace minerals. The 500mg dose aligns with research on testosterone support and performance.

  In healthy men ages 45-55, 500mg daily purified shilajit increased total testosterone by 20.45%, free testosterone by 19.14%, and DHEAS (a testosterone precursor) by 31.35% after 90 days.^[18] These hormonal improvements complement Casanova’s other testosterone-supporting ingredients like Testofen® and tongkat ali.

  Beyond testosterone, shilajit helps maintain muscular strength during fatigue. Research on 500mg daily found it reduced fatigue-induced strength decline from 16-17% to 8.9% while lowering hydroxyproline levels, suggesting improved muscle recovery and connective tissue health.^[19] This makes the ingredient useful for supporting gym performance and daily vitality.

  

  Fulvic acid, shilajit’s primary active component, assists with nutrient delivery and supports cellular energy production.^[20]

• Black Ginger Extract (Kaempferia parviflora) – 500mg

  One of our favorite and most underrated ingredients in the entire industry, black ginger (Kaempferia parviflora) supports blood flow through dual mechanisms that complement the Nitrosigine® in this formula. The extract’s primary active compound, 5,7-dimethoxyflavone, shows PDE5 inhibitory activity similar to pharmaceutical options but at lower affinity, allowing higher doses without the same side effect profile.^[21] This helps maintain healthy cGMP levels in vascular smooth muscle, supporting relaxation and improved blood flow.

  The extract also promotes nitric oxide production in endothelial cells,^[22] creating synergy with Nitrosigine®’s vasodilatory effects. A 2024 meta-analysis covering both animal and human trials showed black ginger extract helps support healthy glucose metabolism and sexual function.^[23] Research in soccer players demonstrates benefits for physical performance,^[24] while human studies show increased energy expenditure.^[25] Traditional Thai medicine has used black ginger for centuries to support vitality and stamina, and this is one of those situations where western science is still catching up. Apollon knows what’s what, though.

  The 500mg dose here is once again large (increased from 300mg in the previous formula), and larger than other amounts we’ve seen in pre-workout support blends. This should provide research-supported levels for vascular and metabolic support, working alongside the formula’s testosterone-supporting and adaptogenic ingredients.

• Pine Bark Extract – 200mg

  Pine bark extract delivers procyanidins and other polyphenols that support healthy blood flow through dual mechanisms. The extract enhances nitric oxide production by activating eNOS (endothelial nitric oxide synthase), which research shows works through phosphorylation pathways that promote vascular relaxation.^[26] These compounds also function as antioxidants, protecting nitric oxide from degradation by reactive oxygen species that would otherwise reduce its bioavailability.^[26]

  

  Apollon Nutrition The Specialist delivers 26 clinically-dosed ingredients for comprehensive organ support. 500mg TUDCA, 1200mg NAC, 1000mg bergamot, plus vitamins and minerals in 10 capsules daily. Pharmaceutical-grade organ protection built for serious athletes.

  Studies on endothelial function and cardiovascular health typically use 100mg to 200mg daily, placing Casanova’s dose at the effective range for supporting vascular function.^[27] The procyanidins are metabolized by gut bacteria into active phenolic acid metabolites that contribute to the extract’s biological effects.^[28]

  This ingredient complements Nitrosigine by supporting healthy NO levels through different pathways, with its antioxidant properties helping maintain the stability of the nitric oxide that other ingredients produce.

• AstraGin® (Astragalus membranaceus and Panax notoginseng) – 50mg

  AstraGin is a patented^[29-33] blend of Astragalus membranaceus and Panax notoginseng extracts that supports nutrient absorption through multiple mechanisms.

  Research shows it upregulates amino acid transporters like CAT1, which helps increase arginine uptake from the intestinal lumen into circulation. In a 2023 human clinical trial, participants taking 50mg AstraGin with arginine showed a 17.3% increase in arginine bioavailability and a 20.8% increase in urinary nitrate levels, indicating enhanced nitric oxide production.^[34] This makes it particularly relevant for Casanova’s 1500mg Nitrosigine® dose, as improving arginine absorption supports the blood flow and performance benefits that define this formula.

How to Use

• Dosing: Take 8 capsules once daily. For those who find this serving size excessive, you can split the dose into 4 capsules twice daily (morning and evening) to maintain consistent blood levels throughout the day.
• Timing flexibility: While daily consistency matters most, you can time your serving pre-workout to take advantage of the blood flow and energy support during training.
• With or without food: Take with food to minimize any potential stomach discomfort from the larger capsule serving.

Apollon Nutrition is back with CreaSmash — the first supplement featuring CreaSol SSAT! Research shows 28% greater strength gains and 51% better endurance vs creatine alone. If you’re serious about your training, this could be the creatine upgrade you’ve been waiting for.

Stacks Well With

• The Specialist: Apollon’s comprehensive organ support formula complements Casanova perfectly for men taking their health seriously across all systems.
• CreaSmash: ATP production benefits pair well with Casanova’s nitric oxide support while adding even more blood flow effects.

Who It’s For

• Men seeking comprehensive vitality support who want clinical doses of proven ingredients rather than underdosed multi-ingredient blends
• Athletes wanting blood flow benefits both in and out of the gym, since the nitric oxide support works for pumps during training
• Users transitioning from more aggressive formulas who want effective support without stimulants like yohimbine
• Men prioritizing sexual health and performance through multiple pathways: blood flow, testosterone support, and stress management

Differences in the 2026 Version

The reformulated Casanova maintains the core blood flow and testosterone support of the original while adding adaptogenic and stress-management ingredients. Here’s what changed:

Added:

• WiS05X® Ashwagandha (600mg) – stress management and testosterone support
• Spilanthes Acmella Extract SA3X™ (500mg) – unique addition to the category
• ASP5X® Purified Shilajit (500mg) – mineral-rich adaptogen
• Pine Bark Extract (200mg) – additional antioxidant and blood flow support

Removed:

• Cellflo6™ Green Tea Extract (600mg)
• Yohimbine HCl (5.4mg)

The removal of yohimbine broadens Casanova’s appeal to users who prefer to avoid this stimulant or who experienced side effects from it.

Upgraded:

• Horny Goat Weed increased from 20% to 30% icariin standardization
• Black Ginger increased from 300mg to 500mg

Maintained:

• Nitrosigine® (1500mg)
• Testofen® Fenugreek (600mg)
• Longjack Tongkat Ali 100:1 (600mg)
• AstraGin® (50mg)

The new formula offers 28 servings (224 capsules) compared to 20 servings (160 capsules) in the original, providing better value while maintaining the 8-capsule serving size. Now you basically get a whole month of action!

Conclusion: Full-Spectrum Male Vitality Without Compromise

Apollon Nutrition’s reformulated Casanova delivers what the brand does best: clinical dosing across a comprehensive ingredient panel with zero proprietary blends. The 2026 version adds stress management through WiS05X® ashwagandha and mineral support through ASP5X® shilajit while maintaining the blood flow and testosterone support that made the original effective.

The removal of yohimbine makes this formula more accessible while the upgraded horny goat weed (30% icariin) and increased black ginger dose (500mg) ensure you’re not sacrificing effectiveness. With 1500mg Nitrosigine® leading the formula, you’re getting nitric oxide support that works both for performance in the gym and vitality outside of it.

For men who want comprehensive support rather than single-ingredient solutions, Casanova covers blood flow, testosterone, stress management, and libido enhancement in one product. The 8-capsule serving size reflects Apollon’s commitment to clinical dosing rather than underdosed convenience.

Long story short… what an epic formula. This one wins in multiple scenarios.

Check PricePlow for availability and pricing, and sign up for Apollon Nutrition news alerts for updates on new products and reformulations.